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Douglas Ruderfer Lab

Precision medicine and genomics for mental health

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Recent publications

Niamh Mullins, Jooeun Kang et al. medRxiv 2020.12.01.20241281; doi: https://doi.org/10.1101/2020.12.01.20241281
Theodore J Morley, Lide Han, Jonathan Morra, Nancy J Cox, Lisa Bastarache, Douglas Ruderfer
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing. medRxiv 2020.07.21.20159491; doi: https://doi.org/10.1101/2020.07.21.20159491

Lide Han, Xuefang Zhao, Mary Lauren Benton, Thaneer Perumal, Ryan L. Collins, Gabriel E. Hoffman, Jessica S. Johnson, Laura Sloofman, Harold Z. Wang, CommonMind Consortium, Kristen J. Brennand, Harrison Brand, Solveig K. Sieberts, Stefano Marenco, Mette A. Peters, Barbara K. Lipska, Panos Roussos, John A. Capra, Michael Talkowski, Douglas M. Ruderfer. Functional annotation of rare structural variation in the human brain. Nat Commun. 2020;11(1):2990. Published 2020 Jun 12. doi:10.1038/s41467-020-16736-1

Kang J, Ruderfer DM. Expanding cultural and ancestral representation in psychiatric genetic studies [published online ahead of print, 2020 Apr 15]. Neuropsychopharmacology. 2020;10.1038/s41386-020-0676-1. doi:10.1038/s41386-020-0676-1

Szatkiewicz JP, Fromer M, Nonneman RJ, et al. Characterization of Single Gene Copy Number Variants in Schizophrenia. Biol Psychiatry. 2020;87(8):736-744. doi:10.1016/j.biopsych.2019.09.023

Douglas M. Ruderfer, Colin G. Walsh, Matthew W. Aguirre, Yosuke Tanigawa, Jessica D. Ribeiro, Joseph C. Franklin & Manuel A. Rivas. Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide. Mol Psychiatry. 2019 Jan 4. doi: 10.1038/s41380-018-0326-8.

Charney AW, Stahl EA, Green EK, Chen CY, Moran JL, Chambert K, Belliveau RA Jr, Forty L, Gordon-Smith K, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Knowles JA, Burdick KE, Jones I, Jones LA, Hultman CM, Perlis R, Purcell SM, McCarroll SA, Pato CN, Pato MT, Di Florio A, Craddock N, Landén M, Smoller JW, Ruderfer DM, Sklar P. Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases. Biol Psychiatry. 2018 Dec 20. pii: S0006-3223(18)32087-0. doi: 10.1016/j.biopsych.2018.12.009.

Ruderfer et al. Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes. Cell 173 (7), 1705-1715. e16

Genovese G, Fromer M, Stahl EA, Ruderfer DM, Chambert K, Landén M, Moran JL, Purcell SM, Sklar P, Sullivan PF, Hultman CM, McCarroll SA. Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia. Nat Neurosci. 2016 Nov;19(11):1433-1441. doi: 10.1038/nn.4402. Epub 2016 Oct 3

Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26.

Ruderfer DM, Hamamsy T, Lek M, Karczewski KJ, Kavanaugh, D, Samocha K, Exome Aggregation Consortium, Daly MJ, MacArthur DG, Fromer M, Purcell SM. Patterns of genic intolerance of rare copy number variations in 59,898 human exomes. Nat Genet. 2016 Aug 17. doi: 10.1038/ng.3638.

Lek M et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 Aug 17;536(7616):285-91. doi: 10.1038/nature19057.

Ruderfer DM, Dudley JT. Deep phenotyping predicts Huntington's genotype. Nat Biotechnol. 2016 Aug 9;34(8):823-4. doi: 10.1038/nbt.3648.

Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2016 May 3;15(5):1024-36. doi: 10.1016/j.celrep.2016.03.090. Epub 2016 Apr 21.

Ruderfer DM, Charney AW, Readhead B, Kidd BA, Kahler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, Sklar P. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. Lancet Psychiatry. 2016 Feb 22. pii: S2215-0366(15)00553-2. doi: 10.1016/S2215-0366(15)00553-2.

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Location at VUMC

2215 Garland Ave.
515B Light Hall
Nashville, TN 37232

Current Openings

Postdoctoral Fellow
Data Scientist

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